Description

2,5-Difluoro-4-Methylaniline is a versatile fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a methyl group on the aromatic ring, which significantly influences the electronic properties and metabolic stability of final compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced efficacy.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the difluoro-methylaniline moiety contributes to improved biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in high-performance displays.
• Organic Electronic Materials: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments with unique color fastness and properties.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex biaryl structures.

Basic Information

Product Name	2,5-Difluoro-4-Methylaniline
CAS No.	878285-14-4
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	4-Methyl-2,5-difluoroaniline; 2,5-Difluoro-p-toluidine; 2,5-Difluoro-4-methylbenzenamine; Benzenamine, 2,5-difluoro-4-methyl-; 4-Amino-2,5-difluorotoluene; 2,5-Difluoro-4-toluidine; 2,5-Difluoro-4-methylphenylamine
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Methylaniline is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality parameters. Our commitment to cGMP principles and regulatory compliance ensures a reliable supply for demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.