Description

Benzenamine, 2-Ethynyl-4-(Trifluoromethyl)- is a specialized aromatic amine building block featuring a unique combination of an ethynyl group and a trifluoromethyl substituent. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and functional materials. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials due to its conjugated ethynyl group.
• Cross-Coupling Reactions: An effective substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create complex alkynyl-linked structures.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.
• Ligand Synthesis: Used to prepare novel ligands for catalysis, leveraging the electron-withdrawing nature of the CF3 group and the coordinating ability of the amine.

Basic Information

Product Name	Benzenamine, 2-Ethynyl-4-(Trifluoromethyl)-
CAS No.	878133-02-9
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	2-Ethynyl-4-(trifluoromethyl)aniline; 2-Ethynyl-4-(trifluoromethyl)benzenamine; 4-(Trifluoromethyl)-2-ethynylaniline; 2-Amino-5-(trifluoromethyl)phenylacetylene; 2-Ethynyl-α,α,α-trifluoro-p-toluidine; 2-Ethynyl-4-trifluoromethylaniline
EINECS	Contact for details

Quality Control

Every batch of Benzenamine, 2-Ethynyl-4-(Trifluoromethyl)- is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents and strong acids. Due to its light-sensitive and easily oxidized nature, minimize exposure to air and light during handling.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.