Description

tert-Butyl 2-(Trifluoromethyl)-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex fused pyridopyrimidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel drug candidates for oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its privileged heterocyclic structure.
• Preclinical Drug Development: Serves as a critical precursor for generating compounds for biological screening and pharmacological evaluation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 2-(Trifluoromethyl)-5,6-Dihydropyrido[3,4-D]Pyrimidine-7(8H)-Carboxylate
CAS No.	877402-39-6
Molecular Formula	C15H17F3N3O2
Molecular Weight	328.31 g/mol
Synonyms	7-tert-Butoxycarbonyl-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; tert-Butyl 2-(trifluoromethyl)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 2-(Trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylic acid tert-butyl ester; 877402-39-6; BOC-protected trifluoromethyl pyridopyrimidine; t-Butyl 2-trifluoromethyl-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and purified to meet exacting standards for pharmaceutical R&D use. Comprehensive analytical data including HPLC purity, NMR, and MS confirmation are generated. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.