Description

3(4H)-Quinazolinebutanamide, 2-Amino-N,G-Dicyclohexyl-n-Methyl-6-Phenoxy-, (Gs)- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a versatile building block with specific stereochemistry. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Used in the pilot-scale and commercial-scale production of active pharmaceutical ingredients requiring a specific (Gs)-configured quinazoline core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Biochemical Research: May be employed as a reference standard or a tool compound in biochemical assays to study specific biological pathways.

Basic Information

Item	Details
Product Name	3(4H)-Quinazolinebutanamide, 2-Amino-N,G-Dicyclohexyl-n-Methyl-6-Phenoxy-, (Gs)-
CAS No.	877032-57-0
Molecular Formula	C31H42N4O2
Molecular Weight	502.70 g/mol
Synonyms	(Gs)-2-Amino-N,G-dicyclohexyl-N-methyl-6-phenoxy-3,4-dihydroquinazoline-4-butanamide; 2-Amino-N,N-dicyclohexyl-N-methyl-6-phenoxy-3,4-dihydroquinazoline-4-butanamide (Gs isomer); (Gs)-877032-57-0; 6-Phenoxy-2-amino-N,N-dicyclohexyl-N-methyl-3,4-dihydroquinazoline-4-butanamide; Quinazolinebutanamide derivative (Gs); Advanced Quinazoline Intermediate (Gs); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of this pharmaceutical intermediate is produced under strict quality management systems to ensure consistency and traceability. Our rigorous quality testing includes identity confirmation, purity assay, and control of specified impurities to meet the exacting standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.