Description

5-Ethyl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in modern medicinal chemistry, particularly for introducing the pyrazolopyrimidine scaffold, which is associated with significant biological activity. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Kinase Inhibitor Research: Serves as a core scaffold for the development of potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry & R&D: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Pre-clinical Development: Employed in the synthesis of compounds for pharmacological profiling, toxicology studies, and formulation development.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery.

Basic Information

Product Name	5-Ethyl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid
CAS No.	876708-67-7
Molecular Formula	C11H12F3N3O2
Molecular Weight	275.23 g/mol
Synonyms	5-Ethyl-7-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 4,5,6,7-Tetrahydro-5-ethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid; 876708-67-7; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid derivative; 5-Ethyl-7-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Ethyl-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications, and our quality documentation is fully traceable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.