Description

6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-6-One, 2-Azido-2,3,3A,9A-Tetrahydro-3-Hydroxy-2-(Hydroxymethyl)-, (2R,3S,3As,9Ar)- CAS NO 876707-99-2 is a high-purity, stereochemically defined heterocyclic compound featuring a complex fused ring system with azido and hydroxymethyl functional groups. This compound serves as a critical advanced intermediate for the synthesis of novel pharmaceutical agents, particularly in antiviral and anticancer research. It is essential for medicinal chemistry teams in pharmaceutical R&D and fine chemical synthesis who require building blocks with precise chirality and reactive handles for further derivatization.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside analogue drugs targeting viral infections.
• Antiviral Drug Discovery: Used as a core scaffold for creating novel compounds with potential activity against a range of viruses.
• Oncology Research: Serves as a precursor in the synthesis of potential chemotherapeutic agents and targeted cancer therapies.
• Medicinal Chemistry: Provides a versatile platform for structure-activity relationship (SAR) studies due to its functionalized oxazolo-pyrimidine core.
• Bioconjugation & Probe Development: The azido group enables click chemistry applications for labeling, imaging, and developing diagnostic probes.
• Academic & Contract Research: Employed in university and CRO laboratories for cutting-edge research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-6-One, 2-Azido-2,3,3A,9A-Tetrahydro-3-Hydroxy-2-(Hydroxymethyl)-, (2R,3S,3As,9Ar)-
CAS No.	876707-99-2
Molecular Formula	C9H9N5O4
Molecular Weight	251.20 g/mol
Synonyms	(2R,3S,3aS,9aR)-2-Azido-2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one; 2-Azido-2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one (2R,3S,3aS,9aR)-; Furo-Oxazolo-Pyrimidinone Azido Diol; Azido-Functionalized Oxazolo[3,2-a]pyrimidine; CAS 876707-99-2
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP-compliant practices ensures reliability and traceability for our pharmaceutical and research partners.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials. Allow the product to reach room temperature in the sealed container before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.