Description

6-Amino-2-(2,3-Dihydro-1H-Indol-1-Yl)Pyrimidin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its fused indole-pyrimidinone heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted drug candidates, especially those with kinase inhibitory activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in academic and industrial R&D labs.
• Biochemical Reagent: Used in biochemical assays and as a reference standard for analytical method development and validation in quality control laboratories.
• Organic Synthesis Building Block: Employed in custom synthesis and contract manufacturing for creating specialized libraries of heterocyclic compounds.

Basic Information

Product Name	6-Amino-2-(2,3-Dihydro-1H-Indol-1-Yl)Pyrimidin-4(3H)-One
CAS No.	876667-59-3
Molecular Formula	C12H12N4O
Molecular Weight	228.25 g/mol
Synonyms	6-Amino-2-(2,3-dihydro-1H-indol-1-yl)-3,4-dihydropyrimidin-4-one; 6-Amino-2-(indolin-1-yl)-3H-pyrimidin-4-one; 1-(6-Amino-4-oxo-1,4-dihydropyrimidin-2-yl)indoline; 2-(Indolin-1-yl)-6-aminopyrimidin-4(3H)-one; 876667-59-3
EINECS	Contact for details

Quality Control

Our production of 6-Amino-2-(2,3-Dihydro-1H-Indol-1-Yl)Pyrimidin-4(3H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support compliance with cGMP standards where required for advanced R&D and pre-clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.