Description

6-(4-Methoxyphenyl)-2-[(4,6,7-Trimethyl-2-Quinazolinyl)Amino]-4(3H)-Pyrimidinone is a high-purity, advanced pharmaceutical intermediate designed for research and development in medicinal chemistry. This compound is valued for its role as a key synthetic building block in the creation of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery projects.
• Biochemical Assay Development: Serves as a reference standard or probe compound in enzymatic and cellular screening assays.
• Academic Research: Employed in university and institutional labs for investigating quinazoline and pyrimidinone-based pharmacophores.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug development pipelines.

Basic Information

Product Name	6-(4-Methoxyphenyl)-2-[(4,6,7-Trimethyl-2-Quinazolinyl)Amino]-4(3H)-Pyrimidinone
CAS No.	876667-53-7
Molecular Formula	C23H21N5O2
Molecular Weight	399.45 g/mol
Synonyms	2-[(4,6,7-Trimethylquinazolin-2-yl)amino]-6-(4-methoxyphenyl)pyrimidin-4(3H)-one; 6-(4-Methoxyphenyl)-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-4(3H)-pyrimidinone; 876667-53-7; Quinazolinylaminopyrimidinone derivative; Kinase inhibitor intermediate; 4(3H)-Pyrimidinone, 6-(4-methoxyphenyl)-2-[(4,6,7-trimethyl-2-quinazolinyl)amino]-
EINECS	Contact for details

Quality Control

Our 6-(4-Methoxyphenyl)-2-[(4,6,7-Trimethyl-2-Quinazolinyl)Amino]-4(3H)-Pyrimidinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable data for critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.