Description

1-(2,3-Difluorophenyl)Piperazine is a specialized fluorinated piperazine derivative, a high-value intermediate in advanced organic synthesis. This compound matters for its role as a critical building block in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety can significantly influence biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of central nervous system (CNS) active drugs, including potential antipsychotics and antidepressants.
• Agrochemical Synthesis: Used in creating novel herbicides and fungicides, where the fluorine atoms enhance lipophilicity and target binding.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis.
• Chemical Biology Research: Employed as a scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	1-(2,3-Difluorophenyl)Piperazine
CAS No.	876379-86-1
Molecular Formula	C10H12F2N2
Molecular Weight	198.21 g/mol
Synonyms	2,3-Difluorophenylpiperazine; 1-(2,3-Difluorophenyl)piperazine; 2,3-Difluoro-1-piperazinobenzene; N-(2,3-Difluorophenyl)piperazine; 2,3-Difluoro-N-(piperazin-1-yl)aniline; 876379-86-1; 1-(2,3-Difluorophenyl)piperazine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our 1-(2,3-Difluorophenyl)Piperazine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects with custom purity grades, including research and GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.