Description

2-tert-Butyl-4-(1-Methylcyclopropyl)-6-(Piperazin-1-Yl)Pyrimidine is a high-value, multi-functional heterocyclic compound featuring a pyrimidine core substituted with a piperazine moiety. This structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry research. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the areas of kinase inhibitors and central nervous system (CNS) drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for drug discovery and lead optimization programs.
• Kinase Inhibitor Development: The structural motifs present are valuable for creating compounds that modulate kinase activity.
• CNS Drug Candidates: Employed in the research and development of potential treatments for neurological disorders.
• Chemical Biology Probes: Utilized to develop tools for studying biological pathways and protein functions.
• Custom Synthesis: A foundational component for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	2-tert-Butyl-4-(1-Methylcyclopropyl)-6-(Piperazin-1-Yl)Pyrimidine
CAS No.	876028-69-2
Molecular Formula	C16H26N4
Molecular Weight	274.41 g/mol
Synonyms	2-(tert-Butyl)-4-(1-methylcyclopropyl)-6-(piperazin-1-yl)pyrimidine; 6-(1-Piperazinyl)-2-(1,1-dimethylethyl)-4-(1-methylcyclopropyl)pyrimidine; 2-tert-Butyl-4-(1-methylcyclopropyl)-6-piperazin-1-ylpyrimidine; 876028-69-2; 2-tert-butyl-4-(1-methylcyclopropyl)-6-(piperazin-1-yl)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-tert-Butyl-4-(1-Methylcyclopropyl)-6-(Piperazin-1-Yl)Pyrimidine is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.