Description

4,5-Difluoro-2-Methylaniline is a high-purity, fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its core value lies in its unique substitution pattern, which makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro-methylaniline moiety can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Polymer & Resin Modifier: Incorporated as a monomer or curing agent to create specialty polymers with enhanced chemical resistance, thermal stability, and specific optical properties.
• Dye & Pigment Precursor: Utilized in the synthesis of high-performance, light-fast fluorinated dyes and pigments for specialized applications.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to form complex biaryl amines.

Basic Information

Product Name	4,5-Difluoro-2-Methylaniline
CAS No.	875664-57-6
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	2-Methyl-4,5-difluoroaniline; 4,5-Difluoro-2-methylbenzenamine; 2-Amino-4,5-difluorotoluene; 4,5-Difluoro-o-toluidine; Benzenamine, 4,5-difluoro-2-methyl-; 4,5-DFMA; 875664-57-6 (CAS)
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Methylaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent lot-to-lot performance. Certificates of Analysis (COA) with full traceability are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and strong oxidizing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.