Description

2-Bromo-4-Fluoro-6-(Trifluoromethyl)Aniline is a high-purity, multi-functional halogenated aniline derivative serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring bromo, fluoro, and trifluoromethyl substituents, makes it an indispensable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeling reagents in biochemical research.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl and aniline structures.

Basic Information

Product Name	2-Bromo-4-Fluoro-6-(Trifluoromethyl)Aniline
CAS No.	875664-27-0
Molecular Formula	C7H4BrF4N
Molecular Weight	258.01 g/mol
Synonyms	2-Bromo-4-fluoro-6-(trifluoromethyl)benzenamine; 2-Bromo-4-fluoro-α,α,α-trifluoro-m-toluidine; Benzenamine, 2-bromo-4-fluoro-6-(trifluoromethyl)-; 875664-27-0; 2-Bromo-4-fluoro-6-trifluoromethylaniline; 6-Amino-3-bromo-5-fluorobenzotrifluoride; 3-Bromo-5-fluoro-α,α,α-trifluoro-6-aminotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Fluoro-6-(Trifluoromethyl)Aniline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade meets a typical purity specification of ≥97% (by HPLC), suitable for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support custom synthesis and can tailor purity grades (including ≥98% and ≥99%) to meet specific project requirements under cGMP conditions if needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.