Description

4-Chloro-1-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound is of critical importance for its role as a key building block in the synthesis of novel, targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of oncology and anti-inflammatory drugs, where precise molecular structure and high chemical purity are non-negotiable for successful API development.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of small molecule kinase inhibitors for targeted cancer therapies.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: A key scaffold in the production route of advanced drug candidates, especially those targeting specific enzymatic pathways.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and inhibition mechanisms in academic and industrial research settings.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	4-Chloro-1-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine-2-Carboxylic Acid
CAS No.	875515-78-9
Molecular Formula	C9H6ClN3O2
Molecular Weight	223.62 g/mol
Synonyms	4-Chloro-1-methyl-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylic acid; 1-Methyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylic acid; 7H-Pyrrolo[2,3-d]pyrimidine-2-carboxylic acid, 4-chloro-1-methyl-; 4-Chloro-1-methyl-1H-pyrrolo[2,3-d]pyrimidine-2-carboxylic acid; 4-Chloro-1-methyl-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylic acid (CAS 875515-78-9)
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-1-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine-2-Carboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and manufacturing processes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under quality systems appropriate for advanced intermediates, including cGMP where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to strong acids and organic solvents, keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.