Description

4-(Difluoromethyl)-2-Fluorobenzaldehyde is a specialized fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique difluoromethyl and fluorine substituents make it a valuable precursor for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated moiety can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and stability.
• Functional Material Development: Employed in the synthesis of specialty polymers, coatings, and advanced materials requiring specific fluorine-based properties like low surface energy or chemical resistance.
• Cross-Coupling Reactions: The aldehyde group is amenable to further functionalization via reactions like Suzuki, Heck, or reductive amination, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Research: An important reagent for academic and industrial research focused on exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	4-(Difluoromethyl)-2-Fluorobenzaldehyde
CAS No.	875222-54-1
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	2-Fluoro-4-(difluoromethyl)benzaldehyde; 4-(Difluoromethyl)-2-fluorobenzenecarboxaldehyde; 2-Fluoro-α,α-difluoro-p-tolualdehyde; Benzaldehyde, 4-(difluoromethyl)-2-fluoro-; 4-(Difluoromethyl)-2-fluorobenzaldehyde; 2-Fluoro-4-difluoromethylbenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-2-Fluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.