Description

3-Chloro-2-Fluoro-4-Iodoaniline is a high-purity halogenated aniline derivative, serving as a critical multi-functional building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Essential for method development, cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), and as a scaffold for creating diverse chemical libraries.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, halogenated dyes and pigments that require specific light-fastness and color properties.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-Iodoaniline
CAS No.	874840-61-6
Molecular Formula	C6H4ClFIN
Molecular Weight	271.46 g/mol
Synonyms	4-Amino-3-chloro-2-fluoroiodobenzene; 3-Chloro-2-fluoro-4-iodobenzenamine; 1-Amino-3-chloro-2-fluoro-4-iodobenzene; Benzenamine, 3-chloro-2-fluoro-4-iodo-; 3-Chloro-2-fluoro-4-iodoaniline; 874840-61-6; 3-Chloro-2-fluoro-4-iodo-phenylamine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoro-4-Iodoaniline is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical applications. Our standard quality commitment includes HPLC purity ≥98% (with higher grades available), identity confirmation via FT-IR and NMR, and stringent control of related substances. A detailed Certificate of Analysis (COA) is supplied with each shipment, and we can support custom specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container has been opened. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.