Description

Fmoc-D-Serine Methyl Ester CAS NO 874817-14-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical chiral building block, enabling the controlled incorporation of D-serine into complex peptide sequences while preventing unwanted side reactions. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in the development of therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the sequential assembly of peptides using Fmoc-chemistry protocols.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic & Conjugate Synthesis: Acts as a precursor for creating modified peptides and peptide-drug conjugates with enhanced stability or bioavailability.
• Chemical Biology & Proteomics Research: Employed in the synthesis of peptide probes, substrates, and inhibitors for studying enzyme function and protein-protein interactions.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and biochemistry.

Basic Information

Product Name	Fmoc-D-Serine Methyl Ester
CAS No.	874817-14-8
Molecular Formula	C19H19NO6
Molecular Weight	357.36 g/mol
Synonyms	Fmoc-D-Ser-OMe; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic acid methyl ester; Methyl (R)-2-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-3-hydroxypropanoate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-serine methyl ester; Fmoc-D-Ser(Me); Fmoc-D-Ser(OMe); D-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Serine Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.