Description

6-Amino-5-(Chloroacetyl)-1-Cyclopropylpyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its pyrimidine-dione core functionalized with amino and chloroacetyl groups. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex nucleoside analogs and other heterocyclic APIs targeting viral and oncological diseases.
• Antiviral Drug Research: Serves as a core scaffold for developing novel antiviral agents, including potential treatments for herpesviruses and other DNA viruses.
• Oncology Drug Discovery: Utilized in medicinal chemistry programs to create new small-molecule inhibitors targeting specific enzymes or pathways in cancer cells.
• Chemical Biology Probes: Used to develop tool compounds for studying enzyme function and cellular signaling pathways due to its reactive chloroacetyl handle.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and GMP production of candidate drugs for clinical trials.
• Agrochemical Intermediate: Potential use in the research and development of new pesticides and fungicides with novel modes of action.

Basic Information

Item	Details
Product Name	6-Amino-5-(Chloroacetyl)-1-Cyclopropylpyrimidine-2,4(1H,3H)-Dione
CAS No.	874754-20-8
Molecular Formula	C9H10ClN3O4
Molecular Weight	259.65 g/mol
Synonyms	1-Cyclopropyl-6-amino-5-(chloroacetyl)pyrimidine-2,4(1H,3H)-dione; 5-(Chloroacetyl)-6-amino-1-cyclopropyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 6-Amino-1-cyclopropyl-5-(2-chloro-1-oxoethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione; 6-Amino-5-chloroacetyl-1-cyclopropyluracil; Cyclopropyl-6-aminouracil chloroacetyl derivative; 874754-20-8; AC1L4BZP; CTK8G0135
EINECS	Contact for details

Quality Control

Our 6-Amino-5-(Chloroacetyl)-1-Cyclopropylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.