Description

5-Chloro-2-Iodopyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This compound is particularly significant for its dual reactive sites, enabling selective functionalization to create complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted drug candidates, especially kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides with novel modes of action.
• Material Science: Serves as a building block for creating functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive iodine atom.
• Nucleoside Analog Synthesis: Employed in the preparation of modified nucleosides and nucleotides for biochemical research.
• Chemical Library Development: Used in combinatorial and parallel synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Chloro-2-Iodopyrimidine
CAS No.	874676-81-0
Molecular Formula	C4H2ClIN2
Molecular Weight	240.43 g/mol
Synonyms	2-Iodo-5-chloropyrimidine; 5-Chloro-2-iodopyrimidine; Pyrimidine, 5-chloro-2-iodo-; 874676-81-0; 5-Chloro-2-iodo-pyrimidine; 2-Iodo-5-chloro-pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Iodopyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.