Description

2-Chloro-4,5-Difluorobenzyl Bromide is a versatile and high-value halogenated benzyl bromide building block essential for advanced organic synthesis. Its molecular structure, featuring chlorine and fluorine substituents on the aromatic ring, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates where the difluoro motif is crucial for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the halogenated benzyl group for enhanced biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Polymer Modification: Used to introduce halogenated benzyl functionalities into polymer chains to alter physical properties like thermal stability or refractive index.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing molecular libraries for screening in medicinal chemistry.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzyl Bromide
CAS No.	874285-21-9
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-4,5-difluorobenzene; (2-Chloro-4,5-difluorophenyl)methyl bromide; 2-Chloro-4,5-difluoro-α-bromotoluene; 4,5-Difluoro-2-chlorobenzyl bromide; Benzene, 1-(bromomethyl)-2-chloro-4,5-difluoro-; α-Bromo-2-chloro-4,5-difluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.