Description

4-Thiazolidinecarboxylic Acid, 3-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Acetyl]-2,2-Dimethyl-, (4R)- is a specialized, high-purity Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and protecting group strategies in the construction of complex peptide sequences. It serves as a key building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides and peptidomimetics. The product is supplied with a guaranteed CAS NO 873842-17-2.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated synthesis of peptides using Fmoc/tert-butyl strategy.
• Pharmaceutical Research & Development: Used in the discovery and development of new peptide-based drugs, including hormones, enzyme inhibitors, and receptor agonists/antagonists.
• Peptidomimetic Design: Incorporates the constrained 2,2-dimethylthiazolidine-4-carboxylic acid scaffold to influence peptide backbone conformation and enhance metabolic stability.
• Bioconjugation and Labeling: Serves as a precursor for creating peptide conjugates with other molecules, such as fluorescent dyes, polymers, or drug payloads.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic and Contract Research: Essential reagent for universities and CROs conducting cutting-edge research in medicinal chemistry and chemical biology.

Basic Information

Product Name	4-Thiazolidinecarboxylic Acid, 3-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Acetyl]-2,2-Dimethyl-, (4R)-
CAS No.	873842-17-2
Molecular Formula	C24H24N2O6S
Molecular Weight	468.52 g/mol
Synonyms	Fmoc-Dmt-OH; Fmoc-2,2-dimethylthiazolidine-4-carboxylic acid; (4R)-3-[(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}acetyl)-2,2-dimethyl-1,3-thiazolidine-4-carboxylic acid; N-α-Fmoc-N-α-(2,2-dimethyl-1,3-thiazolidine-4-carbonyl)glycine; Fmoc-D-2,2-dimethylthiazolidine-4-carboxylic acid; Fmoc-Dmt; Fmoc-Dmt-OH (Dmt = 2,2-dimethylthiazolidine-4-carboxylic acid)
EINECS	Contact for details

Quality Control

Our 4-Thiazolidinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (4R-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.