Description

tert-Butyl 9-((3Ar,4R,6R,6Ar)-6-(Aminomethyl)-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purin-6-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate with a complex nucleoside-like structure. This compound is critical for the synthesis of novel antiviral and anticancer agents, offering a key chiral building block for targeted drug development. It is primarily required by research institutions and pharmaceutical companies engaged in the development of nucleoside analog therapeutics and prodrugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral drugs, particularly those targeting viral polymerases.
• Anticancer Agent Research: Used in the development of nucleoside analog prodrugs designed for targeted cancer therapies.
• Prodrug Synthesis: The tert-butyl carbamate and protected sugar moiety make it a versatile scaffold for constructing prodrugs with improved bioavailability.
• Biochemical Research: Employed in enzymatic studies and as a reference standard in analytical method development for related compounds.
• Custom Synthesis: Acts as a starting material for the custom synthesis of labeled compounds (e.g., deuterated, C13) for metabolic and pharmacokinetic studies.

Basic Information

Item	Details
Product Name	tert-Butyl 9-((3Ar,4R,6R,6Ar)-6-(Aminomethyl)-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purin-6-Ylcarbamate
CAS No.	873556-45-7
Molecular Formula	C19H28N6O5
Molecular Weight	420.46 g/mol
Synonyms	9H-Purin-6-carboxamide, N-[(1R,2S,3R,5R)-5-(aminomethyl)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-N-(1,1-dimethylethoxy)-; BOC-Aminomethyl-Dioxolane Purine Carbamate; tert-Butyl N-[9-[(3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl]carbamate; Protected Adenine Nucleoside Intermediate; (3aR,4R,6R,6aR)-4-[6-[(tert-Butoxycarbonyl)amino]purin-9-yl]-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
EINECS	Contact for details

Quality Control

Our tert-Butyl 9-((3Ar,4R,6R,6Ar)-6-(Aminomethyl)-2,2-Dimethyltetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purin-6-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.