Description

2,3,4-Trifluoro-L-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid L-phenylalanine. This compound is a critical chiral building block in medicinal chemistry, where the strategic introduction of fluorine atoms can dramatically alter a molecule's metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in oncology and CNS disorders.
• Peptide Modification: Used to incorporate fluorinated aromatic side chains into synthetic peptides to enhance their stability, membrane permeability, and biological activity.
• Proteomics & Biochemical Research: Serves as a tool compound for studying enzyme-substrate interactions and metabolic pathways involving phenylalanine analogues.
• Agrochemical Synthesis: Employed in the creation of advanced, fluorinated herbicides and pesticides with improved efficacy and environmental profiles.
• Positron Emission Tomography (PET) Tracer Development: Acts as a precursor for F-18 labeled radiopharmaceuticals used in medical imaging.
• Material Science: A potential monomer for synthesizing specialized fluorinated polymers with unique surface properties.

Basic Information

Product Name	2,3,4-Trifluoro-L-Phenylalanine
CAS No.	873429-58-4
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	(S)-2-Amino-3-(2,3,4-trifluorophenyl)propanoic acid; L-2,3,4-Trifluorophenylalanine; 2,3,4-Trifluoro-DL-phenylalanine (related); F3Phe; 2,3,4-Trifluoro Phe; 2,3,4-TriF-L-Phe; 2,3,4-Trifluorophenylalanine; TFP
EINECS	Contact for details

Quality Control

We supply 2,3,4-Trifluoro-L-Phenylalanine in high-purity grades suitable for research and cGMP manufacturing. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity, chemical purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.