Description

2-(3,5-Difluorophenyl)Aniline is a high-purity, specialized aromatic amine building block featuring a difluorinated phenyl substituent. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical agents, where its unique fluorine substitution pattern can significantly influence biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, CNS agents, and anti-cancer compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluorophenyl group enhances lipophilicity and target binding.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a building block for fluorescent probes, affinity tags, and other molecular tools used in biochemical research.
• Cross-Coupling Reactions: Acts as a versatile substrate in Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed coupling reactions to form complex biaryl structures.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Aniline
CAS No.	873056-60-1
Molecular Formula	C12H9F2N
Molecular Weight	205.20 g/mol
Synonyms	2-(3,5-Difluorophenyl)benzenamine; 2-Amino-3',5'-difluorobiphenyl; 3',5'-Difluoro-[1,1'-biphenyl]-2-amine; 2-(3,5-Difluorophenyl)phenylamine; Benzenamine, 2-(3,5-difluorophenyl)-; 3,5-Difluorobiphenyl-2-ylamine; (3,5-Difluorophenyl)aniline
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.