Description

4-(Trifluoromethoxy)Benzylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound is critical for facilitating the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce the versatile 4-(trifluoromethoxy)benzyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy group for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the benzylboronic acid group enables efficient coupling to construct complex heterocyclic systems.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is required.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and bioconjugates for studying biological pathways and diagnostic applications.

Basic Information

Product Name	4-(Trifluoromethoxy)Benzylboronic Acid
CAS No.	872038-32-9
Molecular Formula	C8H8BF3O3
Molecular Weight	220.0 g/mol
Synonyms	4-(Trifluoromethoxy)benzenemethaneboronic acid; [4-(Trifluoromethoxy)phenyl]methylboronic acid; (4-Trifluoromethoxybenzyl)boronic acid; α-Borono-4-(trifluoromethoxy)toluene; p-(Trifluoromethoxy)benzylboronic acid; 4-(Trifluoromethoxy)benzylboronic acid pinacol ester (protected form); 872038-32-9; B-(4-((Trifluoromethoxy)methyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Benzylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.