Description

Insulin α-Chain (1-13) CAS NO 872036-64-1 is a synthetic peptide fragment corresponding to the first thirteen amino acids of the A-chain of human insulin. This high-purity peptide is a critical intermediate and reference standard for advanced pharmaceutical research and development. It is primarily utilized by biotechnology companies, academic research institutions, and contract research organizations (CROs) focused on diabetes research, peptide hormone studies, and the development of novel therapeutic analogs.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of insulin and its derivatives in method development and validation.
• Biochemical Research: Serves as a key intermediate in structure-activity relationship (SAR) studies to understand insulin's binding and function.
• Peptide Synthesis: Acts as a building block for the solid-phase or solution-phase synthesis of longer insulin fragments or modified analogs.
• Antigen Production: Can be used to generate specific antibodies for immunoassays targeting the insulin α-chain region.
• Metabolic Disorder Studies: Employed in in vitro and ex vivo research models investigating insulin signaling pathways and diabetes mechanisms.
• Quality Control: Essential for the identity testing and impurity profiling of insulin-based active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Insulin α-Chain (1-13)
CAS No.	872036-64-1
Molecular Formula	C64H98N18O21S2
Molecular Weight	1503.73 g/mol
Synonyms	Insulin A-Chain (1-13); Human Insulin A-Chain Fragment 1-13; Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu; H-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-OH; Insulin alpha chain 1-13 peptide; A1-A13 peptide of insulin; Insulin A(1-13)
EINECS	Contact for details

Quality Control

Our Insulin α-Chain (1-13) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.