Description

Benzonitrile, 4-[8-(cyclopropylmethoxy)-7-hydroxy-2-(1-methylethyl)-4-oxo-3(4H)-quinazolinyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily needed by pharmaceutical R&D laboratories and fine chemical producers engaged in developing innovative small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of proprietary drug candidates, especially kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical structure of target active molecules during process development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study specific enzyme interactions and pathways.
• Fine Chemical Production: Acts as a specialized intermediate for synthesizing other complex, high-value organic compounds.

Basic Information

Product Name	Benzonitrile, 4-[8-(cyclopropylmethoxy)-7-hydroxy-2-(1-methylethyl)-4-oxo-3(4H)-quinazolinyl]-
CAS No.	871814-26-5
Molecular Formula	C22H21N3O4
Molecular Weight	391.42 g/mol
Synonyms	4-[8-(Cyclopropylmethoxy)-7-hydroxy-2-isopropyl-4-oxo-3,4-dihydroquinazolin-3-yl]benzonitrile; 7-Hydroxy-8-(cyclopropylmethoxy)-2-isopropyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzonitrile; 3-(4-Cyanophenyl)-7-hydroxy-8-(cyclopropylmethoxy)-2-isopropyl-3,4-dihydroquinazolin-4-one; AGN-PC-0E7Q1P; BDBM50391485; ZINC000006714008; Quinazolinone benzonitrile derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.