Description

Methanimidamide, N'-[1-Cyclopropyl-3-(2-Fluoro-4-Iodophenyl)-1,2,3,6-Tetrahydro-2,6-Dioxo-4-Pyrimidinyl]-N,n-Dimethyl- is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant interest in pharmaceutical research and development. This compound matters for its critical role in the synthesis of novel antiviral agents targeting resistant strains of HIV and other retroviruses. It is primarily needed by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the development of next-generation antiviral therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Antiviral Drug Discovery: Used in medicinal chemistry programs to develop novel compounds with activity against drug-resistant viral strains.
• Biochemical Research: Serves as a reference standard and a tool compound for studying enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Preclinical Development: Employed in the production of batches for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Custom Synthesis: Starting material for the tailored synthesis of analogs and derivatives for specialized research applications.
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up and cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Methanimidamide, N'-[1-Cyclopropyl-3-(2-Fluoro-4-Iodophenyl)-1,2,3,6-Tetrahydro-2,6-Dioxo-4-Pyrimidinyl]-N,n-Dimethyl-
CAS No.	871700-30-0
Molecular Formula	C₁₆H₁₆FIN₄O₂
Molecular Weight	442.23 g/mol
Synonyms	N'-[1-Cyclopropyl-3-(2-Fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl]-N,N-dimethylmethanimidamide; 4-[[(Dimethylamino)methylene]amino]-1-cyclopropyl-5-(2-fluoro-4-iodophenyl)-1,2,3,6-tetrahydro-2,6-pyrimidinedione; NNRTI Intermediate 871700-30-0; 1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-4-[(dimethylamino)methylidene]amino-1,2,3,6-tetrahydropyrimidine-2,6-dione; CAS 871700-30-0
EINECS	Contact for details

Quality Control

Our Methanimidamide, N'-[1-Cyclopropyl-3-(2-Fluoro-4-Iodophenyl)-1,2,3,6-Tetrahydro-2,6-Dioxo-4-Pyrimidinyl]-N,n-Dimethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure compliance with research and development grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.