Description

1-(4-[(Trifluoromethyl)Sulfanyl]Phenyl)Ethan-1-Amine is a specialized aromatic amine building block featuring a trifluoromethylthio (-SCF₃) substituent, a key pharmacophore in modern medicinal chemistry. This compound is valued for its ability to modulate the lipophilicity, metabolic stability, and binding affinity of drug candidates, making it a critical intermediate in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in central nervous system (CNS), antiviral, and oncology therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the -SCF₃ group enhances biological activity and environmental persistence.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent in bio-conjugation and target identification studies due to its unique fluorine signature.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for fine chemical suppliers serving the custom synthesis needs of global biotech and pharma clients.

Basic Information

Product Name	1-(4-[(Trifluoromethyl)Sulfanyl]Phenyl)Ethan-1-Amine
CAS No.	871519-25-4
Molecular Formula	C₉H₈F₃NS
Molecular Weight	219.23 g/mol
Synonyms	1-[4-(Trifluoromethylthio)phenyl]ethanamine; α-Methyl-4-(trifluoromethylthio)benzylamine; 4-(Trifluoromethylthio)phenethylamine, N-substituted; 1-(4-(Trifluoromethylsulfanyl)phenyl)ethanamine; p-(Trifluoromethylthio)phenethylamine; 871519-25-4; 4-SCF3-α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our 1-(4-[(Trifluoromethyl)Sulfanyl]Phenyl)Ethan-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.