Description

4(3H)-Quinazolinone, 2-[4-[(1-Cyclobutyl-4-Piperidinyl)Oxy]Phenyl]-8-Methoxy-3-Methyl- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need this precise molecule to support their synthesis of targeted bioactive compounds. Its defined structure enables the exploration of structure-activity relationships (SAR) in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and SAR studies to develop new chemical entities (NCEs) with targeted biological activity.
• Oncology Drug Development: A key scaffold for the research of novel anti-cancer agents due to the quinazolinone core's known pharmacological relevance.
• CNS-Active Compound Synthesis: Employed in the development of compounds targeting neurological disorders, leveraging its specific structural motifs.
• Biochemical Tool Compound: Utilized in vitro and in vivo studies to probe specific biological pathways and protein functions.
• Custom Synthesis & Scale-Up: Supplied for custom manufacturing projects, from milligram-scale research to kilogram-scale pilot production for clinical trials.

Basic Information

Product Name	4(3H)-Quinazolinone, 2-[4-[(1-Cyclobutyl-4-Piperidinyl)Oxy]Phenyl]-8-Methoxy-3-Methyl-
CAS No.	870997-42-5
Molecular Formula	C25H29N3O3
Molecular Weight	419.52 g/mol
Synonyms	2-[4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl]-8-methoxy-3-methyl-4(3H)-quinazolinone; 8-Methoxy-3-methyl-2-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]-4(3H)-quinazolinone; 870997-42-5; UNII-8V5Q8Q48Y6; 8V5Q8Q48Y6; A-922500; A922500; CHEMBL3186472; BDBM50389339; AKOS025147064.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.