Description

(1S)-(4-Fluoro-3-Methoxyphenyl)Ethylamine is a chiral amine building block of significant importance in modern synthetic chemistry. Its value lies in its enantiopure (1S) configuration and the strategic combination of fluorine and methoxy substituents on the aromatic ring, which are crucial for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for the development of new active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the fluorine atom enhances metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science: A building block for specialty polymers and advanced organic electronic materials requiring specific optoelectronic properties.
• Diagnostic Agent Synthesis: Employed in the creation of radiolabeled probes or contrast agents for medical imaging (e.g., PET tracers).
• Academic & Process Chemistry: A valuable reagent for methodological studies and scale-up process optimization in academic and industrial laboratories.

Basic Information

Product Name	(1S)-(4-Fluoro-3-Methoxyphenyl)Ethylamine
CAS No.	870849-59-5
Molecular Formula	C9H12FNO
Molecular Weight	169.20 g/mol
Synonyms	(1S)-1-(4-Fluoro-3-methoxyphenyl)ethanamine; (S)-1-(4-Fluoro-3-methoxyphenyl)ethylamine; (S)-α-Methyl-4-fluoro-3-methoxybenzylamine; (S)-1-(4-Fluoro-3-methoxyphenyl)ethan-1-amine; (S)-4'-Fluoro-3'-methoxy-α-methylbenzylamine; (S)-1-(4-Fluoro-3-methoxyphenyl)ethanamine; (S)-FMPEA; (1S)-FMPEA
EINECS	Contact for details

Quality Control

Our (1S)-(4-Fluoro-3-Methoxyphenyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or direct light should be avoided. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.