Description

5-Bromo-4-Chloro-7-(Triisopropylsilyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, protected nucleobase analog crucial for advanced organic synthesis. This compound matters as a key synthetic intermediate for constructing modified oligonucleotides and nucleoside analogs, enabling precise molecular design. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing next-generation therapeutics, including antisense oligonucleotides and other nucleic acid-based drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Antisense Oligonucleotide (ASO) Synthesis: Used to introduce modified bases into oligonucleotide sequences to enhance stability, specificity, and pharmacokinetic properties.
• Prodrug Development: Serves as a protected precursor in the design of prodrugs for improved bioavailability and targeted delivery.
• Agrochemical Research: Employed in the research and development of novel agrochemicals that target specific biological pathways.
• Bioconjugation & Labeling: The reactive halogen sites and protected pyrrolopyrimidine core facilitate site-specific bioconjugation for diagnostic and research applications.
• Chemical Biology Probes: Integral for creating molecular probes to study nucleic acid-protein interactions and enzyme mechanisms.

Basic Information

Product Name	5-Bromo-4-Chloro-7-(Triisopropylsilyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	870706-51-7
Molecular Formula	C15H23BrClN3Si
Molecular Weight	404.81 g/mol
Synonyms	4-Chloro-5-bromo-7-(triisopropylsilyl)-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-(triisopropylsilyl)-; 5-Bromo-4-chloro-7-triisopropylsilyl-7H-pyrrolo[2,3-d]pyrimidine; TIPS-Protected 5-Bromo-4-Chloropyrrolopyrimidine; 870706-51-7; 5-Br-4-Cl-7-TIPS-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-7-(Triisopropylsilyl)-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.