Description

3-Chloro-5-Fluoro-4-Hydroxybenzaldehyde is a versatile halogenated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring both chloro and fluoro groups ortho to a formyl group on a phenolic ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobials, and central nervous system (CNS) agents.
• Agrochemical Active Ingredient Precursor: Used in the research and development of new herbicides, fungicides, and pesticides, where the halogen atoms contribute to bioavailability and environmental stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for advanced functional materials, including ligands for metal-organic frameworks (MOFs) and cores for liquid crystal displays or organic light-emitting diodes (OLEDs).
• Fine Chemical & Dye Intermediate: Employed in the production of specialized dyes, pigments, and other high-value fine chemicals requiring specific halogenated aromatic structures.
• Cross-Coupling Reactions: The aldehyde and halogen functionalities make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl systems.
• Academic & Contract Research: Used in university and commercial R&D laboratories for methodological studies and the exploration of new chemical spaces.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Hydroxybenzaldehyde
CAS No.	870704-13-5
Molecular Formula	C7H4ClFO2
Molecular Weight	174.56 g/mol
Synonyms	4-Hydroxy-3-chloro-5-fluorobenzaldehyde; 3-Chloro-5-fluoro-4-hydroxybenzaldehyde; 3-Chloro-5-fluoro-4-hydroxy-benzenecarboxaldehyde; 3-Chloro-5-fluorosalicylaldehyde; Benzaldehyde, 3-chloro-5-fluoro-4-hydroxy-; 870704-13-5 (CAS)
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluoro-4-Hydroxybenzaldehyde is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized, it is recommended to store the material under an inert atmosphere for long-term preservation and to minimize exposure to air and moisture upon opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.