Description

5-[3-Methoxy-4-(4-Methoxy-Benzyloxy)-Benzyl]-Pyrimidine-2,4-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzyl-protected diaminopyrimidine structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly as a key building block in kinase inhibitor synthesis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Reagent: Employed in biochemical assays to study enzyme inhibition mechanisms and cellular signaling pathways.
• Reference Standard: Supplied as a high-purity compound for use as an analytical standard in quality control and method development for API manufacturing.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for preclinical and clinical development.

Basic Information

Product Name	5-[3-Methoxy-4-(4-Methoxy-Benzyloxy)-Benzyl]-Pyrimidine-2,4-Diamine
CAS No.	870483-87-7
Molecular Formula	C21H24N4O3
Molecular Weight	380.44 g/mol
Synonyms	5-[3-Methoxy-4-(4-Methoxybenzyloxy)benzyl]pyrimidine-2,4-diamine; 2,4-Diamino-5-[3-methoxy-4-[(4-methoxyphenyl)methoxy]benzyl]pyrimidine; UNII-9J8K4A8U6C; 9J8K4A8U6C; 870483-87-7; 5-({3-Methoxy-4-[(4-methoxybenzyl)oxy]phenyl}methyl)pyrimidine-2,4-diamine
EINECS	Contact for details

Quality Control

Our 5-[3-Methoxy-4-(4-Methoxy-Benzyloxy)-Benzyl]-Pyrimidine-2,4-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.