Description

Letaxaban CAS NO 870262-90-1 is a potent and selective direct Factor Xa inhibitor, representing a significant class of anticoagulant agents. Its primary value lies in its targeted mechanism of action, which is critical for the research and development of next-generation antithrombotic therapies. This high-purity compound is essential for pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers engaged in the synthesis of novel anticoagulant drugs.

Application

• Pharmaceutical Research & Development: Serves as a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel oral anticoagulants.
• Biochemical Assay Development: Used as a precise tool compound for studying Factor Xa enzyme kinetics, inhibition mechanisms, and structure-activity relationships (SAR).
• Reference Standard Manufacturing: Provides a certified high-purity material for use in quality control (QC) and analytical method validation within pharmaceutical production.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate pharmacokinetics, pharmacodynamics, efficacy, and safety profiles of anticoagulant candidates.
• Chemical Synthesis: Acts as a crucial building block or final target molecule for medicinal chemists synthesizing Factor Xa inhibitor analogs.

Basic Information

Product Name	Letaxaban
CAS No.	870262-90-1
Molecular Formula	C23H22ClN5O4
Molecular Weight	467.90 g/mol
Synonyms	TAK-442; Letaxaban (TAK442); N-[5-[2-(Aminocarbonyl)phenyl]-2-(hydroxymethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-3-yl]-5-chloro-2-thiophenecarboxamide; 5-Chloro-N-[2-(hydroxymethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-3-yl)-5-(2-carbamoylphenyl)thiophene-2-carboxamide; TAK 442
EINECS	Contact for details

Quality Control

Our Letaxaban is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.