Description

(3,3-Difluoropyrrolidin-1-Yl)[(2S,4S)-4-[4-(Pyrimidin-2-Yl)Piperazin-1-Yl]Pyrrolidin-2-Yl]Methanone is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined molecular architecture. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly as a key building block for targeted small molecule drugs. It is primarily sought by R&D teams and process chemists in the pharmaceutical and biotechnology industries for applications in oncology, CNS disorders, and other areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional degrader molecules.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors due to the presence of the pyrimidinyl-piperazine moiety.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Process Development & Scale-up: Serves as a reference standard and starting material for developing robust, scalable synthetic routes for GMP production.

Basic Information

Item	Detail
Product Name	(3,3-Difluoropyrrolidin-1-Yl)[(2S,4S)-4-[4-(Pyrimidin-2-Yl)Piperazin-1-Yl]Pyrrolidin-2-Yl]Methanone
CAS No.	869490-23-3
Molecular Formula	C18H24F2N6O
Molecular Weight	378.42 g/mol
Synonyms	(2S,4S)-1-[(3,3-Difluoropyrrolidin-1-yl)carbonyl]-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidine; (3,3-Difluoropyrrolidin-1-yl)-[(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl]methanone; UNII-0Q0I4I6F9G; 0Q0I4I6F9G; SCHEMBL2180415; BDBM50389375; AKOS025244065; AS-76311
EINECS	Contact for details

Quality Control

Our (3,3-Difluoropyrrolidin-1-Yl)[(2S,4S)-4-[4-(Pyrimidin-2-Yl)Piperazin-1-Yl]Pyrrolidin-2-Yl]Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.