Description

(αs)-α-(Difluoromethyl)-Benzenemethanamine Hydrochloride CAS NO 869377-79-7 is a specialized chiral amine hydrochloride salt, characterized by a difluoromethyl group on the benzylic carbon, which imparts unique electronic and metabolic properties. This compound serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas requiring fluorinated analogs for enhanced potency and stability.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of novel fluorinated pesticides and herbicides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and the creation of fluorinated analog libraries for drug discovery programs.
• Asymmetric Synthesis: Serves as a chiral amine source or auxiliary in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Chemical Biology: Utilized as a probe or linker in the development of biochemical tools and diagnostic agents.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers or ligands with specific fluorine-containing functionalities.

Basic Information

Product Name	(αs)-α-(Difluoromethyl)-Benzenemethanamine Hydrochloride
CAS No.	869377-79-7
Molecular Formula	C8H10ClF2N
Molecular Weight	193.62 g/mol
Synonyms	α-(Difluoromethyl)benzylamine hydrochloride; (R/S)-α-(Difluoromethyl)benzylamine hydrochloride; 1-(Difluoromethyl)-1-phenylethanamine hydrochloride; Benzenemethanamine, α-(difluoromethyl)-, hydrochloride (1:1); (RS)-α-(Difluoromethyl)benzylamine HCl; 1-Phenyl-1-(difluoromethyl)methanamine hydrochloride; (rac)-α-(Difluoromethyl)benzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (αs)-α-(Difluoromethyl)-Benzenemethanamine Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm the racemic mixture, ensuring compliance with research and development standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (approx. 50:50 enantiomeric ratio)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.