Description

3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyluridine is a key fluorinated nucleoside derivative, specifically engineered for advanced pharmaceutical research and synthesis. This compound serves as a critical synthetic intermediate in the development of novel antiviral and anticancer therapeutics, particularly for modifying RNA structure and function. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity building blocks for nucleoside-based drug discovery programs.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Employed in creating chemotherapeutic agents that incorporate fluorinated pyrimidine structures.
• Biochemical Tool: Acts as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism and processing.
• Prodrug Synthesis: The acetyl protecting groups make it a versatile starting material for designing prodrugs with enhanced bioavailability.
• Oligonucleotide Synthesis: Used for the site-specific incorporation of modified nucleotides into oligonucleotides for therapeutic and diagnostic applications.

Basic Information

Product Name	3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyluridine
CAS No.	869355-34-0
Molecular Formula	C₁₄H₁₇FN₂O₈
Molecular Weight	360.29 g/mol
Synonyms	5-Fluoro-2'-O-methyl-3',5'-di-O-acetyluridine; 2'-O-Methyl-5-fluoro-3',5'-di-O-acetyluridine; 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 3',5'-diacetate (related); 5-Fluoro-2'-O-methyluridine 3',5'-diacetate; FMAU 3',5'-diacetate (common abbreviation); 2'-O-Methyl-5-fluorouridine 3',5'-diacetate
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-5-Fluoro-2'-o-Methyluridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.