Description

(E)-5-[2-(2-Carboxyvinyl)]-2'-Deoxyuridine n-Hydroxy-Succimide Ester is a high-purity, activated ester derivative of a modified deoxyuridine nucleoside, designed for efficient bioconjugation. This compound is a critical intermediate for researchers and manufacturers developing advanced oligonucleotide probes, diagnostic assays, and targeted therapeutic agents. It is primarily utilized in pharmaceutical R&D, molecular biology, and the synthesis of novel nucleotide-based conjugates where precise and stable linkage to amines is required.

Application

• Synthesis of fluorescently labeled nucleotides for in situ hybridization (FISH) and other detection platforms.
• Preparation of oligonucleotide-peptide conjugates for targeted drug delivery and cell-penetrating studies.
• Development of diagnostic probes and biosensors requiring covalent attachment to solid supports or reporter molecules.
• Production of affinity purification reagents, such as biotinylated or other tagged nucleotides.
• Research into antiviral and anticancer nucleoside analogs as a key synthetic building block.
• Cross-linking agent in the study of nucleic acid-protein interactions.

Basic Information

Item	Detail
Product Name	(E)-5-[2-(2-Carboxyvinyl)]-2'-Deoxyuridine n-Hydroxy-Succimide Ester
CAS No.	869355-24-8
Molecular Formula	C₁₆H₁₇N₃O₉
Molecular Weight	395.32 g/mol
Synonyms	5-Carboxyvinyl-2'-deoxyuridine NHS Ester; 5-[(E)-2-Carboxyethenyl]-2'-deoxyuridine N-Hydroxysuccinimide Ester; dU-CE NHS Ester; 5-(2-Carboxyvinyl)-2'-deoxyuridine Active Ester; 5-Carboxyvinyldeoxyuridine N-Succinimidyl Ester; Modified Nucleoside NHS Ester; CAS 869355-24-8
EINECS	Contact for details

Quality Control

Our (E)-5-[2-(2-Carboxyvinyl)]-2'-Deoxyuridine n-Hydroxy-Succimide Ester is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for production and control, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.