Description

5-Fluoro-2'-o-Methyl-4-(Methylthio)Pyrimidin-2-One is a high-purity, fluorinated pyrimidinone derivative with a methylthio substituent, serving as a critical advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research, where its specific substitution pattern enables targeted molecular modifications. It is primarily needed by R&D laboratories, custom synthesis houses, and pharmaceutical manufacturers engaged in developing nucleoside analogs and other fine chemicals for therapeutic applications.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel nucleoside analog drugs.
• Antiviral Drug Development: Used in the preparation of experimental compounds targeting viral polymerases.
• Oncology Research: Serves as a precursor in the development of potential anticancer agents, particularly those involving pyrimidine metabolism inhibition.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of client-specific, high-value fine chemicals.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies and proteomics research.
• Agrochemical Intermediate: Potential use in the synthesis of advanced fungicides or herbicides.

Basic Information

Product Name	5-Fluoro-2'-o-Methyl-4-(Methylthio)Pyrimidin-2-One
CAS No.	869222-67-3
Molecular Formula	C7H7FN2OS
Molecular Weight	186.21 g/mol
Synonyms	5-Fluoro-2-methoxy-4-(methylthio)pyrimidine; 4-(Methylthio)-5-fluoro-2-methoxypyrimidine; 5-Fluoro-2-methoxy-4-methylsulfanylpyrimidine; 869222-67-3; 5-Fluoro-2-O-methyl-4-(methylthio)pyrimidin-2-one; 5-Fluoro-4-(methylthio)-2-methoxypyrimidine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2'-o-Methyl-4-(Methylthio)Pyrimidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring GMP-grade intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.