Description

Acetamide, n-(6-Amino-7-Methoxy-4-Quinazolinyl)-n-(3-Chloro-4-Fluorophenyl)- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments. Our supply is characterized by stringent quality control, ensuring batch-to-batch consistency for critical synthesis pathways.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted small-molecule drugs.
• Oncology Research: Used in R&D for developing novel chemotherapeutic agents targeting specific cancer pathways.
• Biochemical Research: Serves as a reference standard and a tool compound in enzymatic and cellular assay studies.
• Fine Chemical Synthesis: Building block for constructing complex quinazoline-based molecular architectures in custom synthesis projects.
• API Development: Employed in the process development and scale-up of active pharmaceutical ingredients (APIs) under GMP guidelines.

Basic Information

Product Name	Acetamide, n-(6-Amino-7-Methoxy-4-Quinazolinyl)-n-(3-Chloro-4-Fluorophenyl)-
CAS No.	869199-62-2
Molecular Formula	C₁₇H₁₅ClFN₅O₂
Molecular Weight	375.78 g/mol
Synonyms	N-(6-Amino-7-methoxyquinazolin-4-yl)-N'-(3-chloro-4-fluorophenyl)urea; 1-(3-Chloro-4-fluorophenyl)-3-(6-amino-7-methoxy-4-quinazolinyl)urea; Afatinib Impurity; Afatinib Intermediate; BIBW 2992 Intermediate; (3-Chloro-4-fluorophenyl)-[6-(7-methoxyquinazolin-4-ylamino)]-urea; Giotrif Intermediate; Gilotrif Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to rigorous quality testing protocols to ensure it meets the exacting standards required for pharmaceutical development. Each batch is analyzed using validated methods including HPLC, NMR, and MS to confirm identity, purity, and impurity profile. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all critical quality attributes. We support development under quality systems suitable for GMP manufacturing and can provide regulatory starting material documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.