Description

(2S,5S,2'S,5'R)-Dihydroxylysinonorleucine is a stereochemically defined, non-proteinogenic amino acid derivative and a specific isomer of lysine cross-links. This compound is of significant interest in biochemical research, particularly in the study of advanced glycation end-products (AGEs) and collagen cross-linking mechanisms. It serves as a critical reference standard and analytical tool for researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors investigating protein modifications, aging, and related metabolic disorders.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the identification and quantification of specific collagen cross-links in tissue samples.
• Diagnostic Development: Employed in the development and calibration of assays (e.g., ELISA, LC-MS/MS) for detecting biomarkers of diabetes, aging, and connective tissue diseases.
• Pharmaceutical Analysis: Acts as a critical standard in analytical method development and validation for drugs targeting AGE-related pathways.
• Metabolic Studies: Utilized in research focused on the Maillard reaction, non-enzymatic glycation, and their role in age-related and diabetic complications.
• Quality Control: Serves as a certified reference material (CRM) for ensuring the accuracy and precision of analytical results in contract research organizations (CROs) and testing labs.
• Nutritional Science Research: Applied in studies investigating the impact of diet on collagen integrity and advanced glycation end-product formation.

Basic Information

Item	Detail
Product Name	(2S,5S,2'S,5'R)-Dihydroxylysinonorleucine
CAS No.	869111-63-7
Molecular Formula	C12H24N2O6
Molecular Weight	292.33 g/mol
Synonyms	DHLNL; (2S,5S)-Dihydroxylysinonorleucine; Lysinonorleucine, dihydroxy-; (2S,5S,2'S,5'R)-DHLNL; (2S,5S)-2,5-Dihydroxylysinonorleucine; (2S,5S)-2,5-Dihydroxy-L-norleucine-L-lysine; AGE Cross-link Standard; Collagen Cross-link Isomer
EINECS	Contact for details

Quality Control

Our (2S,5S,2'S,5'R)-Dihydroxylysinonorleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the container should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.