Description

(2S,5R,2'S,5'R)-Dihydroxylysinonorleucine is a stereochemically defined, non-proteinogenic amino acid derivative that serves as a critical biochemical marker. This compound is of significant value in advanced research and diagnostic applications due to its role as a specific crosslink biomarker for collagen and elastin maturation. It is primarily sought by researchers and developers in the fields of biomedical research, clinical diagnostics, and pharmaceutical development, particularly for studies related to connective tissue disorders, aging, and metabolic bone diseases.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of collagen and elastin cross-linking mechanisms.
• Clinical Diagnostics: Serves as a critical calibrant and control in LC-MS/MS assays for quantifying collagen turnover biomarkers in biological fluids (e.g., urine, serum).
• Pharmaceutical R&D: Employed in the development and validation of therapeutic agents targeting fibrosis, osteoporosis, and cardiovascular diseases.
• Nutraceutical Analysis: Used to assess the efficacy of anti-aging or connective tissue health supplements by measuring specific metabolic endpoints.
• Forensic & Doping Control: Potential application as a reference material in specialized forensic toxicology or anti-doping testing for collagen-related abuse.

Basic Information

Product Name	(2S,5R,2'S,5'R)-Dihydroxylysinonorleucine
CAS No.	869111-52-4
Molecular Formula	C12H24N2O6
Molecular Weight	292.33 g/mol
Synonyms	DHLNL; (2S,5R)-Dihydroxylysinonorleucine; Lysinonorleucine, dihydroxy-; (2S,5R,2'S,5'R)-2,5-Dihydroxylysinonorleucine; Collagen Crosslink; Pyridinoline Crosslink Precursor; (2S,5R)-2,5-Dihydroxylysinonorleucine; (2S,5R)-DH-LNL
EINECS	Contact for details

Quality Control

Our (2S,5R,2'S,5'R)-Dihydroxylysinonorleucine is manufactured under strict quality systems to ensure the high purity and stereochemical integrity required for research and diagnostic applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% (2S,5R,2'S,5'R isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.