Description

4-Fluoro-2-Iodo-5-(Trifluoromethyl)Benzenamine is a high-value, multi-functional aromatic amine building block characterized by its unique halogenated and trifluoromethyl-substituted structure. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research where its fluorine and iodine atoms offer strategic sites for further functionalization. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Intermediate in the production of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Product Name	4-Fluoro-2-Iodo-5-(Trifluoromethyl)Benzenamine
CAS No.	868692-49-3
Molecular Formula	C7H4F4IN
Molecular Weight	304.99 g/mol
Synonyms	4-Fluoro-2-iodo-5-(trifluoromethyl)aniline; 2-Iodo-4-fluoro-5-(trifluoromethyl)aniline; 5-Amino-2-fluoro-4-iodobenzotrifluoride; Benzenamine, 4-fluoro-2-iodo-5-(trifluoromethyl)-; 868692-49-3; 4-Fluoro-2-iodo-5-trifluoromethylphenylamine; 2-Fluoro-4-amino-5-iodobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Iodo-5-(Trifluoromethyl)Benzenamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.