Description

2-Bromo-5-Chloro-4-(Trifluoromethoxy)Aniline is a high-value halogenated aniline derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring bromine, chlorine, and trifluoromethoxy substituents, makes it indispensable for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions, enabling the rapid exploration of chemical space in medicinal and process chemistry.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized, high-performance colorants and functional dyes.

Basic Information

Product Name	2-Bromo-5-Chloro-4-(Trifluoromethoxy)Aniline
CAS No.	868406-81-9
Molecular Formula	C7H4BrClF3NO
Molecular Weight	290.47 g/mol
Synonyms	2-Bromo-5-chloro-4-(trifluoromethoxy)benzenamine; 4-Amino-2-bromo-5-chloro-1-(trifluoromethoxy)benzene; 2-Bromo-5-chloro-α,α,α-trifluoro-p-anisidine; Benzenamine, 2-bromo-5-chloro-4-(trifluoromethoxy)-; 868406-81-9; 2-Bromo-5-chloro-4-trifluoromethoxyaniline
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Chloro-4-(Trifluoromethoxy)Aniline is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical applications. A detailed Certificate of Analysis (COA), confirming identity, purity, and impurity profiles via validated methods (HPLC, GC, NMR), is supplied with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.