Description

1-(2-Thienyl)-3-(2,3,4-Trifluoroanilino)-1-Propanone is a high-purity, specialized organic intermediate featuring a unique trifluorinated aniline and thiophene-based structure. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought by research and development teams and process chemists in the fine chemical and life science industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of new drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in medicinal chemistry for structure-activity relationship (SAR) studies and biochemical assay development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	1-(2-Thienyl)-3-(2,3,4-Trifluoroanilino)-1-Propanone
CAS No.	868255-72-5
Molecular Formula	C₁₃H₁₀F₃NOS
Molecular Weight	285.28 g/mol
Synonyms	3-(2,3,4-Trifluoroanilino)-1-(thiophen-2-yl)propan-1-one; 1-Propanone, 1-(2-thienyl)-3-[(2,3,4-trifluorophenyl)amino]-; 3-Amino-1-(2-thienyl)-3-(2,3,4-trifluorophenyl)propan-1-one; 2,3,4-Trifluoro-N-[3-(2-thienyl)-3-oxopropyl]aniline; 868255-72-5; TFAP Intermediate
EINECS	Contact for details

Quality Control

Every batch of 1-(2-Thienyl)-3-(2,3,4-Trifluoroanilino)-1-Propanone is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the stringent requirements of our global clientele. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.