Description

Pam2Csk4 CAS NO 868247-72-7 is a synthetic lipopeptide derivative, specifically a diacylated lipopeptide, widely recognized as a potent and selective agonist for Toll-like receptor 2 (TLR2). This compound is crucial for fundamental immunological research and advanced therapeutic development, serving as a key tool to stimulate innate immune responses. It is primarily needed by researchers and developers in the fields of immunology, vaccine adjuvants, and novel immunotherapies.

Application

• Immunological Research: As a standard agonist to study TLR2 signaling pathways, macrophage activation, and cytokine production.
• Vaccine Adjuvant Development: Investigated for its potential to enhance the efficacy of vaccines by modulating and strengthening the immune response.
• Cancer Immunotherapy: Used in preclinical studies to activate dendritic cells and other antigen-presenting cells to boost anti-tumor immunity.
• Innate Immunity Studies: Essential for exploring host defense mechanisms against bacterial and fungal pathogens.
• Inflammatory Disease Models: Employed to induce and study controlled inflammatory responses in various experimental models.
• Cell Culture & In Vitro Assays: Used to stimulate immune cells in culture for functional assays and screening applications.

Basic Information

Product Name	Pam2Csk4
CAS No.	868247-72-7
Molecular Formula	C46H87N11O9
Molecular Weight	938.25 g/mol
Synonyms	Pam2Cys-SKKKK; S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine; TLR2 agonist Pam2CSK4; Synthetic Lipopeptide Pam2CysSK4; (2S)-2-Amino-3-({(2R)-2-[(2S)-2-Amino-3-({(2R)-2-[(2S)-2-Amino-3-({(2R)-2-[(2S)-2-Amino-3-({(2R)-2-[(2S)-2-Amino-3-({(2R)-2,3-Bis(palmitoyloxy)propyl]sulfanyl}propanoyl]amino}propanoyl]amino}propanoyl]amino}propanoyl]amino}propanoyl]amino}propanoic acid; BPPcysMPEG; TLR-2 Agonist
EINECS	Contact for details

Quality Control

Our Pam2Csk4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including purity determination by HPLC and identity confirmation by mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.