Description

Benzaldehyde, 3-Iodo-5-(Trifluoromethyl)- CAS NO 868166-28-3 is a highly functionalized aromatic aldehyde, distinguished by the strategic combination of iodine and trifluoromethyl substituents on its benzene ring. This unique structure makes it a versatile and valuable advanced intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development teams in life sciences and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry: An important reagent for introducing the pharmacologically beneficial trifluoromethyl group into more complex molecular architectures.

Basic Information

Product Name	Benzaldehyde, 3-Iodo-5-(Trifluoromethyl)-
CAS No.	868166-28-3
Molecular Formula	C8H4F3IO
Molecular Weight	300.02 g/mol
Synonyms	3-Iodo-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)-3-iodobenzaldehyde; 3-Iodo-α,α,α-trifluoro-m-tolualdehyde; m-Iodo-α,α,α-trifluorobenzaldehyde; Benzaldehyde, m-iodo-α,α,α-trifluoro-; 868166-28-3; 3-Iodo-5-trifluoromethylbenzaldehyde
EINECS	Contact for details

Quality Control

Our high-purity Benzaldehyde derivative is manufactured under strict quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with your specifications. Our quality management system supports cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.