Description

tert-Butyl Tetrahydropyrimidine-1(2H)-Carboxylate is a versatile Boc-protected heterocyclic building block of significant importance in modern synthetic chemistry. Its primary value lies in serving as a key protected intermediate for the synthesis of complex pharmaceutical molecules and advanced agrochemicals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing the tetrahydropyrimidine pharmacophore.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific heterocyclic scaffolds.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex nitrogen-containing heterocycles via further functionalization.
• Peptidomimetics & PROTACs: Serves as a precursor in the design and synthesis of peptidomimetic compounds and Proteolysis-Targeting Chimeras (PROTACs).
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl Tetrahydropyrimidine-1(2H)-Carboxylate
CAS No.	867065-85-8
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	1-Boc-1,2,3,4-Tetrahydropyrimidine; 1,2,3,4-Tetrahydropyrimidine-1-carboxylic acid tert-butyl ester; tert-Butyl 1,2,3,4-tetrahydropyrimidine-1-carboxylate; 1-N-Boc-tetrahydropyrimidine; Boc-THP; N-Boc-1,2,3,4-tetrahydropyrimidine; 1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydropyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl Tetrahydropyrimidine-1(2H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.