Description

Fmoc-12-Amino-4,7,10-Trioxadodecanoic Acid is a specialized, heterobifunctional polyethylene glycol (PEG) derivative featuring an Fmoc-protected amino group and a carboxylic acid terminus. This compound is engineered to serve as a critical spacer or linker molecule, providing solubility, flexibility, and reduced immunogenicity in bioconjugation and peptide synthesis. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, water-soluble linkers for developing peptide-drug conjugates, antibody-drug conjugates (ADCs), and other advanced therapeutic modalities.

Application

• Peptide Synthesis: Used as a hydrophilic, flexible spacer to incorporate PEG chains into solid-phase peptide synthesis (SPPS), improving the solubility and pharmacokinetic properties of synthetic peptides.
• Antibody-Drug Conjugate (ADC) Development: Acts as a key linker component to connect cytotoxic payloads to monoclonal antibodies, enhancing stability and therapeutic index.
• Bioconjugation & Protein Labeling: Facilitates the site-specific attachment of dyes, probes, or other molecules to proteins and biomolecules via its amine-reactive and carboxyl-reactive ends.
• Drug Delivery Systems: Incorporated into nanoparticle and polymer-drug conjugate designs to improve drug solubility, circulation time, and targeted delivery.
• Material Science & Surface Modification: Employed to create PEGylated surfaces on biomaterials, reducing protein fouling and improving biocompatibility.
• Diagnostic Reagent Formulation: Utilized in the development of diagnostic assays and imaging agents that require stable, water-soluble linker chemistry.

Basic Information

Product Name	Fmoc-12-Amino-4,7,10-Trioxadodecanoic Acid
CAS No.	867062-95-1
Molecular Formula	C26H31NO8
Molecular Weight	485.53 g/mol
Synonyms	Fmoc-NH-PEG3-COOH; Fmoc-15-Amino-4,7,10,13-Tetraoxapentadecanoic Acid (common misnomer); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-12-amino-4,7,10-trioxadodecanoic Acid; 3,6,9-Trioxa-12-azatetradecanedioic acid, 12-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-PEG3-acid; Fmoc-Amino-PEG3-COOH; Fmoc-N-amido-PEG3-acid; Fmoc-NH-(CH2CH2O)3-CH2CH2COOH
EINECS	Contact for details

Quality Control

Our Fmoc-12-Amino-4,7,10-Trioxadodecanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.