Description

tert-Butyl 3-Fluoro-4-Formylbenzoate is a high-purity, versatile aromatic building block featuring both a formyl and a tert-butyl ester functional group. This compound is specifically engineered to serve as a critical intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise structural control. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated benzoate scaffold.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores in advanced electronic and display materials.
• Polymer Chemistry: Employed in the creation of specialty monomers and polymers with tailored properties for high-performance materials.
• Cross-Coupling Reactions: The formyl group makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed coupling reactions to create biaryl structures.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	tert-Butyl 3-Fluoro-4-Formylbenzoate
CAS No.	866625-12-9
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	3-Fluoro-4-formylbenzoic acid tert-butyl ester; 4-(tert-Butoxycarbonyl)-2-fluorobenzaldehyde; Benzoic acid, 3-fluoro-4-formyl-, 1,1-dimethylethyl ester; tert-Butyl 3-fluoro-4-formylbenzoate; 2-Fluoro-4-(tert-butoxycarbonyl)benzaldehyde; 1,1-Dimethylethyl 3-fluoro-4-formylbenzoate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 3-Fluoro-4-Formylbenzoate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to meet the stringent standards expected in pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.